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产品信息
PA5-143302
产品规格
种属反应
Human,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence DVSNQLARVCYSPD (aa 106-119).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933941
产品详细信息
Additional Information: This antibody is expected to recognize both reported isoforms (NP_000841.1; NP_671489.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
靶标信息
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.
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生物信息学
蛋白别名: glutathione S-alkyltransferase M4; glutathione S-aralkyltransferase M4; glutathione S-aryltransferase M4; glutathione S-transferase M4; glutathione S-transferase mu 3; Glutathione S-transferase Mu 4; GST class-mu 4; GST-Mu2; GSTM4-4; GTS-Mu2; Leukotriene C4 synthase GSTM4; S-(hydroxyalkyl)glutathione lyase M4; testis tissue sperm-binding protein Li 60n
基因别名: GSTM4; GSTM4-4; GTM4
UniProt ID: (Human) Q03013, (Rat) Q5BK56
Entrez Gene ID: (Human) 2948, (Rat) 499689
