Fabgennix

GTP cyclohydrolase 1 Polyclonal Antibody, Biotin

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产品信息

GTPCH1-2-BIOTIN

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

免疫组化 (IHC)

1:50-1:250

-

酶联免疫吸附实验 (ELISA)

1:10,000

-

免疫沉淀 (IP)

1:50-1:250

-

产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide taken within amino acid region 25-75 on mouse GTPCHI protein.

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偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: GTP cyclohydrolase 1; GTP cyclohydrolase I; GTP-CH-I

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基因别名: Gch; Gch1; GTP-CH; GTPCH

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UniProt ID: (Mouse) Q05915, (Rat) P22288

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Entrez Gene ID: (Mouse) 14528, (Rat) 29244

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nucleotide binding catalytic activity GTP cyclohydrolase I activity calcium ion binding GTP binding zinc ion binding hydrolase activity GTP-dependent protein binding protein homodimerization activity metal ion binding coenzyme binding protein binding hydrolase metabolite interconversion enzyme

参与通路

protein complex assembly tetrahydrobiopterin biosynthetic process metabolic process regulation of blood pressure regulation of lung blood pressure response to interferon-gamma response to tumor necrosis factor vasodilation dopamine biosynthetic process pteridine-containing compound biosynthetic process negative regulation of blood pressure tetrahydrofolate biosynthetic process response to pain neuromuscular process controlling posture positive regulation of nitric-oxide synthase activity dihydrobiopterin metabolic process protein homooligomerization protein heterooligomerization response to lipopolysaccharide 7,8-dihydroneopterin 3'-triphosphate biosynthetic process