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产品信息
H00054676-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GTPBP2 (NP_061969.3, 1 a.a. approximately 602 a.a) full-length human protein.
偶联物
Unconjugated
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDSRVSELFG GCCRPGGGPA VGGTLKARGA GSSSGCGGPK GKKKNGRNRG GKANNPPYLP PEAEDGNIEY KLKLVNPSQY RFEHLVTQMK WRLQEGRGEA VYQIGVEDNG LLVGLAEEEM RASLKTLHRM AEKVGADITV LREREVDYDS DMPRKITEVL VRKVPDNQQF LDLRVAVLGN VDSGKSTLLG VLTQGELDNG RGRARLNLFR HLHEIQSGRT SSISFEILGF NSKGEVVNYS DSRTAEEICE SSSKMITFID LAGHHKYLHT TIFGLTSYCP DCALLLVSAN TGIAGTTREH LGLALALKVP FFIVVSKIDL CAKTTVERTV RQLERVLKQP GCHKVPMLVT SEDDAVTAAQ QFAQSPNVTP IFTLSSVSGE SLDLLKVFLN ILPPLTNSKE QEELMQQLTE FQVDEIYTVP EVGTVVGGTL SSGICREGDQ LVVGPTDDGC FLELRVCSIQ RNRSACRVLR AGQAATLALG DFDRALLRKG MVMVSPEMNP TICSVFEAEI VLLFHATTFR RGFQVTVHVG NVRQTAVVEK IHAKDKLRTG EKAVVRFRFL KHPEYLKVGA KLLFREGVTK GIGHVTDVQA ITAGEAQANM GF
靶标信息
Small G proteins act as molecular switches for regulation of variety of cellular processes, such as nuclear transport, signal transduction, membrane trafficking and protein synthesis. GTPBP2 (GTP-binding protein 2) is a 602 amino acid G protein that is expressed in kidney, skeletal muscle, testis, brain and thymus, though it is not detected in liver. Expression of GTPBP2 is enhanced by ©-interferon stimulation in HeLa cells, THP-1 cells and thioglycollate-elicited mouse peritoneal macrophages. There are four isoforms of GTPBP2 that are expressed as a result of alternative splicing events. Since mutation of the gene encoding GTPBP1 does not lead to any phenotypic abnormalities, it is thought that there may be a genetic redundancy to make up for GTPBP1 lack-of-function. GTPBP2 shares 44% sequence similarity with GTPBP1 and also overlaps in expression pattern, suggesting that the GTPBP2 gene may compensate for GTPBP1 genetic abnormalities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GTP-binding protein 2; GTPBP2
基因别名: GTPBP2
UniProt ID: (Human) Q9BX10
Entrez Gene ID: (Human) 54676
