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GluR4 Antibody (PA5-24217) in IHC (P)
Immunohistochemistry analysis of GluR4 in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with GluR4 polyclonal antibody (Product # PA5-24217) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
产品信息
PA5-24217
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 259-287 amino acids from the central region of human GRIA4
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2541717
产品详细信息
This antibody is predicted to react with non-human primate and rat based on sequence homology.
靶标信息
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AMPA-selective glutamate receptor 4; GluA4; GluR-4; GluR-D; glutamate receptor; Glutamate receptor 4; glutamate receptor channel alpha 4; Glutamate receptor ionotropic, AMPA 4; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 4; spike wave 1
基因别名: GluA4; Glur-4; GluR-D; GLUR4; GLUR4C; Gluralpha4; GLURD; GRIA4; spkw1
UniProt ID: (Human) P48058, (Mouse) Q9Z2W8
Entrez Gene ID: (Human) 2893, (Mouse) 14802
transport
glutamate receptor signaling pathway
chemical synaptic transmission
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
response to fungicide
ion transport
synaptic transmission, glutamatergic
modulation of synaptic transmission
positive regulation of synaptic transmission, glutamatergic
