Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 2
GluR4 (GluA4) (extracellular) Antibody (AGC-019-200UL) in IHC (F)
Expression of GRIA4 (GluR4) in rat DRG - Immunohistochemical staining of rat frozen dorsal root ganglion (DRG) sections using Anti-GluR4 (GluA4) (extracellular) Antibody (#AGC-019), (1:100). GRIA4 is expressed in all the DRG neurons (red). Hoechst 33342 is used as the counterstain (blue).
产品信息
AGC-019-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KLMDRWKKLDQRE, corresponding to amino acid residues 274-286 of rat GluR4, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: AMPA-selective glutamate receptor 4; GluA4; GluR-4; GluR-D; glutamate receptor; Glutamate receptor 4; glutamate receptor channel alpha 4; Glutamate receptor ionotropic, AMPA 4; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 4; glutamate receptor, ionotropic, AMPA4 (alpha 4); spike wave 1
基因别名: GluA4; Glur-4; GluR-D; GLUR4; GLUR4C; Gluralpha4; GLURD; GRIA4; spkw1
UniProt ID: (Human) P48058, (Mouse) Q9Z2W8, (Rat) P19493
Entrez Gene ID: (Human) 2893, (Mouse) 14802, (Rat) 29629
transport
glutamate receptor signaling pathway
chemical synaptic transmission
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
response to fungicide
ion transport
synaptic transmission, glutamatergic
modulation of synaptic transmission
positive regulation of synaptic transmission, glutamatergic
regulation of synapse structure or activity
