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产品信息
PA5-50668
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region derived from internal residues of human glucagon receptor
偶联物
形式
Liquid
浓度
2.7 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636120
产品详细信息
The antibody detects endogenous levels of total GCGR / Glucagon Receptor protein.
靶标信息
Glucagon receptors are G-protein coupled receptors for glucagon and play a central role in the regulation of blood glucose levels and glucose homeostatsis. It regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Glucagon receptors also play an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of down-stream effectors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: GL-R; Glucagon receptor; glucagon receptor perhaps same as Niddm3
基因别名: GCGR; GGR; GL-R; GR
UniProt ID: (Human) P47871, (Mouse) Q61606, (Rat) P30082
Entrez Gene ID: (Human) 2642, (Mouse) 14527, (Rat) 24953
generation of precursor metabolites and energy
exocytosis
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
response to nutrient
regulation of blood pressure
hormone-mediated signaling pathway
glucose homeostasis
response to starvation
positive regulation of GTPase activity
regulation of glycogen metabolic process
cellular response to glucagon stimulus
signal transduction
G-protein coupled receptor signaling pathway
