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产品信息
PA5-18677
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (NQFGKQEPGENSE) corresponding to the internal amino acids of GPX3 (aa 102-114).
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10980999
产品详细信息
This antibody is predicted to react with canine, human and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.
靶标信息
Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site (4-5).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Extracellular glutathione peroxidase; extracellular GPx; Glutathione peroxidase 3; glutathione peroxidase 3 (plasma); GPx-3; GPx-P; Plasma glutathione peroxidase; plasma GPx
基因别名: AA960521; EGPx; GPx; GPx-P; GPX3; GPXP; GSHPx-3; GSHPx-P
UniProt ID: (Human) P22352, (Mouse) P46412
Entrez Gene ID: (Human) 2878, (Mouse) 14778
