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Invitrogen
H4ac pan-acetyl (K5,K8,K12) Polyclonal Antibody
高级验证
This Antibody was verified by Peptide array to ensure that the antibody binds to the antigen stated.
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H4ac pan-acetyl (K5,K8,K12) Antibody (PA5-40083) in ChIP-seq
ChIP was performed with 0.5 µg of Acetyl-Histone H4 (Lys5 + Lys8 + Lys12) polyclonal antibody (Product # PA5-40083) on sheared chromatin from 100,000 K562 cells. The IP'd DNA was subsequently analyzed on a Genome Analyzer. The 36 bp tags were aligned to the human genome using the ELAND algorithm. Figure 2 shows the signal distribution along the complete length of chromosome 2 (figure 2A) and a zoomin to a 6... View More
产品信息
PA5-40083
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide corresponding to human the region of histone H4 containing the acetylated lysines 5, 8 and 12 (H4K5,8,12ac).
偶联物
形式
Liquid
浓度
0.76 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.05% sodium azide, 0.05% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2608361
靶标信息
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetyl Histone H4; Acetyl-H4 K5 K8 K12; Acetyl-H4 Lys5 Lys8 Lys12; Acetyl-Histone H4 K5 K8 K12; Acetyl-Histone H4 Lys5 Lys8 Lys12; H4 ac pan-acetyl; H4 histone family, member A; H4 histone family, member E; H4 histone family, member I; H4 histone family, member J; H4 histone family, member M; H4 histone family, member N; H4 histone, family 2; H4ac; H4K12; H4K12a; H4K12ac; H4K5; H4K5,8,12ac; H4K5ac; H4K8; H4K8ac; H4Lys5,8,12ac; HIST1H4; histone 1, H4a; histone 1, H4b; histone 1, H4e; histone 1, H4i; histone 1, H4j; histone 2, H4; histone 2, H4a; Histone 4; Histone 4 family, member M; histone 4, H4; Histone Cluster 4; histone family member; Histone H4; Histone H4 acetyl; Histone H4A; Histone H4K12; Histone H4K5; Histone H4K8; histone IV, family 2
基因别名: dJ160A22.2; FO108; H4; H4-12; H4-16; H4-53; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4/p; H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4f16; H4F2; H4F2iv; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; H4M; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; Hist1h4m; HIST2H4; HIST2H4A; HIST2H4B; HIST4H4; X04652
UniProt ID: (Human) P62805, (Mouse) Q811M0, (Mouse) P62806
Entrez Gene ID: (Human) 8359, (Human) 8366, (Human) 8367, (Human) 8294, (Human) 8363, (Human) 8370, (Human) 121504, (Mouse) 326619, (Mouse) 326620, (Mouse) 319158, (Mouse) 97122
chromatin silencing at rDNA
double-strand break repair via nonhomologous end joining
nucleosome assembly
DNA replication-dependent nucleosome assembly
DNA replication-independent nucleosome assembly
DNA-templated transcription, initiation
telomere capping
gene silencing by RNA
telomere organization
CENP-A containing nucleosome assembly
cellular protein metabolic process
negative regulation of megakaryocyte differentiation
negative regulation of gene expression, epigenetic
positive regulation of gene expression, epigenetic
protein heterotetramerization
beta-catenin-TCF complex assembly
