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A suggested positive control is mouse liver tissue lysate.
PA5-20774 can be used with blocking peptide PEP-0888.
HAAO (3-Hydroxyanthranilate 3, 4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 3-HAO; 3-HAO {ECO:0000255|HAMAP-Rule:MF_03019}; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate 3,4-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03019}; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilate oxygenase {ECO:0000255|HAMAP-Rule:MF_03019}; 3-hydroxyanthranilic acid dioxygenase; 3-hydroxyanthranilic acid dioxygenase {ECO:0000255|HAMAP-Rule:MF_03019}; HAAO; HAD; HAD {ECO:0000255|HAMAP-Rule:MF_03019}
基因别名: 0610007K21Rik; 0610012J07Rik; 3-HAO; 3-HAOxase; 3HAO; HAAO; HAO
UniProt ID: (Human) P46952, (Mouse) Q78JT3, (Rat) P46953
Entrez Gene ID: (Human) 23498, (Mouse) 107766, (Rat) 56823