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1 µg/mL of MA5-45402 was sufficient for detection of HCN1 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 100kDa. No cross-reactivity against HCN2.
HCN1 includes Hyperpolarization-activated cation channels of the HCN gene family, which contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BCNG-1; Brain cyclic nucleotide-gated channel 1; HAC-2; Hyperpolarization-activated cation channel 2; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
基因别名: BCNG-1; BCNG1; C630013B14Rik; EIEE24; HAC-2; HAC2; HCN1
UniProt ID: (Human) O60741, (Mouse) O88704, (Rat) Q9JKB0
Entrez Gene ID: (Human) 348980, (Mouse) 15165, (Rat) 84390