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产品信息
PA5-11242
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 920-952 amino acids from the C-terminal region of human HDAC7
偶联物
形式
Liquid
纯化类型
Size-exclusion - Dialysis, Ammonium sulfate precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2116640
靶标信息
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HD7; HD7a; hdac-7; Histone deacetylase 7; Histone deacetylase 7A; Protein deacetylase HDAC7
基因别名: HD7; HD7A; HDAC7; HDAC7A
UniProt ID: (Human) Q8WUI4
Entrez Gene ID: (Human) 51564
chromatin binding
transcription corepressor activity
protein kinase C binding
protein binding
SUMO transferase activity
protein kinase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
activating transcription factor binding
metal ion binding
repressing transcription factor binding
14-3-3 protein binding
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
transcription, DNA-templated
cell-cell junction assembly
chromatin modification
protein sumoylation
neuron differentiation
negative regulation of interleukin-2 production
negative regulation of osteoblast differentiation
neuron apoptotic process
histone H3 deacetylation
cellular response to mechanical stimulus
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of neuron death
negative regulation of NIK/NF-kappaB signaling
