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Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).[supplied by OMIM].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Endogenous retrovirus group FRD member 1; endogenous retrovirus group FRD, member 1; Envelope polyprotein; FLJ41944; FLJ90611; HERV-FRD; HERV-FRD provirus ancestral Env polyprotein; HERV-FRD_6p24.1 provirus ancestral Env polyprotein; MGC87585; Synb; syncytin 2; Syncytin-2; Syncytin2
基因别名: envFRD; ERVFRD-1; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD; UNQ6191; UNQ6191/PRO20218
UniProt ID: (Human) P60508
Entrez Gene ID: (Human) 405754