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HES5 Antibody (720168) in WB
Western blot analysis was performed on nuclear and tissue extracts (30 µg lysate) of U-87 MG (Lane 1), Rat Brain (Lane 2), Mouse Spleen (Lane 3) and HEK-293 (Lane 4). The blots were probed with Anti-HES5 Rabbit Polyclonal Antibody (Product # 720168, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A 18 kDa band corresponding to HES5 protein was observed. Known quantity of protein samples were electrophoresed u... View More
产品信息
720168
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptides corresponding to Human HES5 (aa 1-166)
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2633198
产品详细信息
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Mouse, Sheep and Bovine
靶标信息
Hairy and Enhancer-of-split homologues 5 (HES5) is a helix-loop-helix transcriptional factor that negatively regulates cell differentiation during embryogenesis. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. HES5 is reported to be a down stream effector of the Notch Signaling Pathway and is expressed in advanced ovarian serous adenocarcinomas as well as in cervical squamous carcinoma. Reports also suggest that HES5 is abundantly expressed in osteoarthritis along with Notch1 and Jagged1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHb38; Class B basic helix-loop-helix protein 38; Hairy and enhancer of split 5; RP3-395M20.5; Transcription factor HES-5
基因别名: BHLHB38; Hes-5; HES5
UniProt ID: (Human) Q5TA89, (Rat) Q03062, (Mouse) P70120
Entrez Gene ID: (Human) 388585, (Rat) 79225, (Mouse) 15208
negative regulation of transcription from RNA polymerase II promoter
chondrocyte differentiation
transcription, DNA-templated
protein complex assembly
cell adhesion
Notch signaling pathway
smoothened signaling pathway
brain development
positive regulation of cell proliferation
oligodendrocyte development
telencephalon development
glial cell fate commitment
forebrain radial glial cell differentiation
neural tube development
central nervous system myelination
positive regulation of BMP signaling pathway
regulation of myelination
auditory receptor cell differentiation
positive regulation of tyrosine phosphorylation of Stat3 protein
auditory receptor cell fate determination
camera-type eye development
regulation of cell differentiation
regulation of auditory receptor cell differentiation
negative regulation of neuron differentiation
positive regulation of Notch signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
cell maturation
positive regulation of smooth muscle cell proliferation
astrocyte differentiation
negative regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
regulation of epithelial cell proliferation
regulation of neurogenesis
cartilage development
inner ear receptor stereocilium organization
comma-shaped body morphogenesis
S-shaped body morphogenesis
specification of loop of Henle identity
metanephric nephron tubule morphogenesis
establishment of epithelial cell polarity
neuronal stem cell population maintenance
negative regulation of stem cell differentiation
negative regulation of pro-B cell differentiation
negative regulation of forebrain neuron differentiation
negative regulation of inner ear receptor cell differentiation
transcription from RNA polymerase II promoter
neuron differentiation
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
nervous system development
cell differentiation
