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HGK Antibody (PA5-104232) in IHC (P)
Immunohistochemistry analysis of HGK in human ovarian cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with HGK polyclonal antibody (Product # PA5-104232) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-104232
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MAP4K4(Accession O95819), corresponding to amino acid residues E410-R460.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853556
产品详细信息
Antibody detects endogenous levels of total MAP4K4.
靶标信息
MAP4K4 (HGK) is a serine/threonine kinase which plays an important role in stress-activated MAPK core signaling pathways, the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epididymis secretory protein Li 31; FLJ10410; FLJ20373; FLJ90111; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; mitogen activated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4; NCK interacting kinase; Nck-interacting kinase; Ste20 group protein kinase HGK
基因别名: 9430080K19Rik; AU043147; AU045934; AW046177; FLH21957; HEL-S-31; HGK; KIAA0687; MAP4K4; MEKKK4; NIK
UniProt ID: (Human) O95819, (Mouse) P97820
Entrez Gene ID: (Human) 9448, (Mouse) 26921, (Rat) 301363
creatine kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
non-receptor serine/threonine protein kinase
protein phosphorylation
signal transduction by protein phosphorylation
microvillus assembly
intracellular signal transduction
negative regulation of apoptotic process
regulation of JNK cascade
MAPK cascade
response to stress
regulation of mitotic cell cycle
negative regulation of neuron projection development
phosphorylation
stress-activated protein kinase signaling cascade
activation of protein kinase activity
regulation of apoptotic process
neuron projection morphogenesis
negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of neuron projection regeneration
regulation of catalytic activity
