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Invitrogen
HIF-2 alpha Monoclonal Antibody (ep190b)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
图: 1 / 10
HIF-2 alpha Antibody (MA1-16519) in ICC/IF
Immunofluorescence analysis of HIF-2 alpha was performed using 70% confluent log phase MCF7 treated with Cobalt Chloride (150 µM for 48hrs). The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with HIF-2 alpha Monoclonal Antibody (ep190b) (Product # MA1-16519) at... View More
产品信息
MA1-16519
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Hamster,
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
ep190b
抗原
Synthetic peptid corresponding to residues 535-631 of human HIF-2 alpha.
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein G
保存液
PBS with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2098238
产品详细信息
Suggested positive control: antigen standard for EPAS1 (transient overexpression lysate).
靶标信息
HIF-2 alpha (Epas1) is a transcription factor involved in the induction of genes regulated by oxygen. HIF-2 alpha contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. It also regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of the lungs. Mutations in this gene are associated with erythrocytosis familial type 4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; endothelial PAS domain protein 1; Endothelial PAS domain-containing protein 1; EPAS-1; Hif like protein; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF-2 alpha; HIF-2-alpha; HIF-related factor; HIF1 alpha-like factor; HIF1alpha-like factor; HIF2 alpha; HIF2-alpha; HLF; HLF (HIF1alpha-like factor); HRF; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2 alpha; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; mHLF; PAS domain-containing protein 2
基因别名: BHLHE73; ECYT4; EPAS1; HIF-2alpha; HIF2A; HLF; HRF; MOP2; PASD2
UniProt ID: (Human) Q99814, (Mouse) P97481, (Rat) Q9JHS1
Entrez Gene ID: (Bovine) 282711, (Human) 2034, (Mouse) 13819, (Chinese hamster) 100771160, (Rat) 29452
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
protein binding
transcription factor binding
histone acetyltransferase binding
sequence-specific DNA binding
protein heterodimerization activity
transcription factor activity, sequence-specific DNA binding
signal transducer activity
protein dimerization activity
basic helix-loop-helix transcription factor
angiogenesis
response to hypoxia
embryonic placenta development
blood vessel remodeling
regulation of heart rate
transcription from RNA polymerase II promoter
mitochondrion organization
signal transduction
visual perception
erythrocyte differentiation
lung development
somatic stem cell population maintenance
norepinephrine metabolic process
surfactant homeostasis
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
positive regulation of transcription from RNA polymerase II promoter
cell maturation
myoblast fate commitment
iron ion homeostasis
regulation of transcription from RNA polymerase II promoter in response to hypoxia
cellular response to hypoxia
transcription, DNA-templated
regulation of transcription, DNA-templated
response to oxidative stress
multicellular organism development
hemopoiesis
cell differentiation
