Invitrogen

HIP1 Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

1 篇参考文献

查看其他18个HIP1抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (10)
高级验证 (2)

HIP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HIP1 Antibody (PA5-53068) in IHC (P)

Immunohistochemical analysis of HIP1 in human testis using HIP1 Polyclonal Antibody (Product # PA5-53068) using Anti-HIP1 antibody HPA013606.

HIP1 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

HIP1 Antibody — Relative expression in western blot: Antibody specificity was demonstrated by detection of known differential basal expression of the target across tissue/cell models. Expression of HIP1 was observed specifically in A-549 cells and in Caco-2 cells using anti-HIP1 Polyclonal Antibody (Product # PA5-53068) in western blot. The relative expression levels of HIP1 within each cell line is shown using RNA-Seq. {RE}

产品信息

PA5-53068

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:500

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human HIP1. Recombinant protein control fragment (Product #RP-90751).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2642440

产品详细信息

Immunogen sequence: NFLRASALSE HISPVVVIPA EASSPDSEPV LEKDDLMDMD ASQQNLFDNK FDDIFGSSFS SDPFNFNSQN GVNKDEKDHL IERLYREISG LKAQLENMKT ESQRVVLQLK GHVSELEADL AEQQHLRQQA ADDCEFLRAE LDELRRQRED

Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.

靶标信息

Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.

Nature communications

Grosch M,Schraft L,Chan A,Küchenhoff L,Rapti K,Ferreira AM,Kornienko J,Li S,Radke MH,Krämer C,Clauder-Münster S,Perlas E,Backs J,Gotthardt M,Dieterich C,van den Hoogenhof MMG,Grimm D,Steinmetz LM

PA5-53068 was used in Immunohistochemistry-immunofluorescence to highlight the potential of base editors combined with AAVMYO to achieve gene repair for treatment of hereditary cardiac diseases.