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Invitrogen
HMGB2 Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
产品信息
PA5-62773
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642476
产品详细信息
Immunogen sequence: AKGKSEAGKK GPGRPTGSKK KNEP
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 96%.
靶标信息
HMGB2 encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: High mobility group protein 2; High mobility group protein B2; high-mobility group (nonhistone chromosomal) protein 2; high-mobility group box 2; HMG 2; HMG B2; HMG-2; HMG-B2; HMGB-2
基因别名: HMG2; HMGB2
UniProt ID: (Human) P26583
Entrez Gene ID: (Human) 3148
four-way junction DNA binding
enhancer sequence-specific DNA binding
DNA binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
drug binding
DNA binding, bending
protein domain specific binding
chemoattractant activity
transcription regulatory region DNA binding
non-sequence-specific DNA binding, bending
poly(A) RNA binding
RAGE receptor binding
supercoiled DNA binding
positive regulation of endothelial cell proliferation
inflammatory response to antigenic stimulus
DNA topological change
apoptotic DNA fragmentation
chromatin organization
nucleosome assembly
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatid nucleus differentiation
male gonad development
positive regulation of nuclease activity
DNA geometric change
response to lipopolysaccharide
positive regulation of interferon-beta production
V(D)J recombination
response to drug
positive regulation of DNA binding
innate immune response
positive regulation of innate immune response
positive regulation of erythrocyte differentiation
positive regulation of megakaryocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to steroid hormone
regulation of neurogenesis
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive chemotaxis
DNA ligation involved in DNA repair
cell chemotaxis
cellular response to lipopolysaccharide
regulation of stem cell proliferation
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
