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HMGCR Antibody (PA5-116698) in ICC/IF
Immunofluorescence analysis of HMGCR in NIH/3T3 cells. Samples were incubated with HMGCR Polyclonal antibody (Product # PA5-116698) using a dilution of 1:100. Blue: DAPI for nuclear staining.
产品信息
PA5-116698
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 351-440 of HMGCR (NP_0008501)
偶联物
Unconjugated
形式
Liquid
浓度
0.39 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2901329
产品详细信息
Positive Samples: 293T, K-562
Immunogen sequence: KNPITSPVVT QKKVPDNCCR REPMLVRNNQ KCDSVEEETG INRERKVEVI KPLVAETDTP NRATFVVGNS SLLDTSSVLV TQEPEIELPR
靶标信息
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; MGC103269
基因别名: 3H3M; HMG-CoAR; HMGCR; LDLCQ3; Red
UniProt ID: (Human) P04035, (Mouse) Q5U4I2, (Rat) P51639
Entrez Gene ID: (Human) 3156, (Mouse) 15357, (Rat) 25675
hydroxymethylglutaryl-CoA reductase (NADPH) activity
protein binding
hydroxymethylglutaryl-CoA reductase activity
protein homodimerization activity
coenzyme binding
protein phosphatase 2A binding
NADPH binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
NADP binding
oxidoreductase
reductase
metabolite interconversion enzyme
cholesterol biosynthetic process
ubiquinone metabolic process
aging
response to nutrient
isoprenoid biosynthetic process
visual learning
negative regulation of striated muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
coenzyme A metabolic process
positive regulation of stress-activated MAPK cascade
negative regulation of MAP kinase activity
myoblast differentiation
response to ethanol
negative regulation of vasodilation
positive regulation of skeletal muscle tissue development
positive regulation of smooth muscle cell proliferation
protein tetramerization
oxidation-reduction process
negative regulation of wound healing
negative regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of ERK1 and ERK2 cascade
lipid metabolic process
steroid biosynthetic process
steroid metabolic process
cholesterol metabolic process
positive regulation of cell proliferation
embryo development
sterol biosynthetic process
negative regulation of apoptotic process
farnesyl diphosphate biosynthetic process, mevalonate pathway
