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产品信息
A304-053A-T
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Between 550 and 600
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
靶标信息
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: albumin proximal factor; hepatic nuclear factor 1; Hepatocyte nuclear factor 1-alpha; hnf-1 alpha; HNF-1-alpha; interferon production regulator factor; LFB1; Liver-specific transcription factor LF-B1; TCF-1; Transcription factor 1; transcription factor 1, hepatic
基因别名: HNF-1A; HNF1; HNF1A; IDDM20; LFB1; MODY3; TCF-1; TCF1
UniProt ID: (Human) P20823
Entrez Gene ID: (Human) 6927
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription regulatory region DNA binding
protein dimerization activity
DNA-binding transcription factor
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of pronephros size
renal glucose absorption
glucose homeostasis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
glucose import
positive regulation of transcription initiation from RNA polymerase II promoter
