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HNF4A Antibody (417800) in IHC (P)
Immunohistochemistry analysis of HNF4 alpha7 in paraffin-embedded human large intestine. The sample was incubated in HNF4 alpha7 monoclonal antibody (Product # 417800) at a dilution of 3 μg/mL. Section was fixed with 10% formalin-fixed in immersion, activated by autoclave at 121°C for 15 minutes, and blocked with 3% H2O2 in methanol.
产品信息
417800
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
H6939
抗原
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human HNF4--alpha (1-16 aa).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
physiological saline
内含物
0.1% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Wet ice
RRID
AB_2532198
产品详细信息
This antibody specifically recognizes human HNF4 alpha 7- 9 and cross reacts with mouse and rat HNF4 alpha 7- 9.
靶标信息
Hepatocyte nuclear factor 4 alpha (HNF4 alpha) is an orphan nuclear receptor. HNF4a is expressed in the liver, kidney, intestine, and pancreas. Mutation of HNF4a in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4a gene is alternatively spliced and may generate up to nine different isoforms, HNF4a1 through HNF4a9.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: alpha transcription factor 4; FLJ39654; hepatic nuclear factor 4 alpha; hepatic nuclear factor 4, alpha; hepatocyte nuclear factor 4, alpha; Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; HNF4 alpha; HNF4-alpha; HNF4alpha10; HNF4alpha10/11/12; HNF4alpha11; HNF4alpha12; Nuclear receptor 2A1; Nuclear receptor subfamily 2 group A member 1; TCF-14; Transcription factor 14; Transcription factor HNF-4
基因别名: FRTS4; HNF-4; HNF4; HNF4A; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14
UniProt ID: (Human) P41235, (Mouse) P49698, (Rat) P22449
Entrez Gene ID: (Human) 3172, (Mouse) 15378, (Rat) 25735
fatty-acyl-CoA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
receptor binding
fatty acid binding
protein binding
zinc ion binding
palmitoyl-CoA hydrolase activity
protein homodimerization activity
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor binding
sequence-specific DNA binding
metal ion binding
repressing transcription factor binding
C4 zinc finger nuclear receptor
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
ornithine metabolic process
lipid metabolic process
acyl-CoA metabolic process
xenobiotic metabolic process
establishment of tissue polarity
sex differentiation
blood coagulation
negative regulation of cell proliferation
response to glucose
regulation of gastrulation
regulation of lipid metabolic process
signal transduction involved in regulation of gene expression
cell differentiation
negative regulation of cell growth
intracellular receptor signaling pathway
regulation of microvillus assembly
negative regulation of protein import into nucleus, translocation
response to drug
negative regulation of tyrosine phosphorylation of Stat5 protein
glucose homeostasis
steroid hormone mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
cell-cell junction organization
positive regulation of gluconeogenesis
positive regulation of fatty acid biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin secretion
response to cAMP
lipid homeostasis
phospholipid homeostasis
SMAD protein signal transduction
triglyceride homeostasis
negative regulation of activation of JAK2 kinase activity
positive regulation of cholesterol homeostasis
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
