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产品信息
PA5-57288
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642491
产品详细信息
Immunogen sequence: TSDDLTQMLD NLGLKYECYD LLSTMDISDC FIDGNENGDL LWDFLTETCN FNATAPPDLR AELGKDLQEP EFSAKKEGKV LFNNTLSFIV IEA
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 83%.
靶标信息
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.
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生物信息学
蛋白别名: Histamine N-methyltransferase; HMT
基因别名: HMT; HNMT; HNMT-S1; HNMT-S2; MRT51
UniProt ID: (Human) P50135
Entrez Gene ID: (Human) 3176
histamine catabolic process
response to tumor cell
histidine catabolic process
hyperosmotic response
brain development
respiratory gaseous exchange
response to amine
methylation
response to immobilization stress
response to cocaine
response to glucocorticoid
response to interleukin-1
positive regulation of protein targeting to mitochondrion
