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Immunogen sequence: MASSMRSLFS DHGKYVESFR RFLNHSTEHQ CMQEFMDKKL PGIIGRIGDT KSEIKILSIG GGAGEIDLQI LSKVQAQYPG VCINNEVVEP SAEQIAKYKE LVAKTSNLEN VKFAWHKETS SEYQSRMLEK KELQKWDFIH MIQMLYYVKD IPATLKFFHS LLGTNAKMLI IVVSGSSGWD KLWKKYGSRF PQDDLCQYIT SDDLTQMLDN LGLKYECYDL LSTMDISDCF IDGNENGDLL WDFLTETCNF NATAPPDLRA ELGKDLQEPE FSAKKEGKVL FNNTLSFIVI EA; Positive Samples: HT-29, HepG2, HeLa, Mouse liver, Mouse kidney, Mouse brain; Cellular Location: Cytoplasm
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Histamine N-methyltransferase; HMT
基因别名: 1500031F01Rik; AI788969; HMT; HNMT; HNMT-S1; HNMT-S2; MRT51
UniProt ID: (Human) P50135, (Mouse) Q91VF2
Entrez Gene ID: (Human) 3176, (Mouse) 140483