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产品信息
MA5-32042
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
SP08-07
抗原
Synthetic peptide within Human HO-1 aa 227-276
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809336
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules, biliverdin and carbon monoxide. HO consists of two homologous isozymes, an inducible HO-1 and a constitutively expressed HO-2. HO-1 is induced by a wide variety of stimuli including conditions of oxidative stress, inflammatory agents, transforming growth factor beta and heat shock. The increase in expression of HO-1 is thought to be a cellular defense mechanism against oxidative stress since elevated HO could eventually generate more bilirubin, an anti-oxidant.
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生物信息学
蛋白别名: heat shock protein, 32-kD; heme orygenase 1; heme oxygenase (decycling) 1; Heme oxygenase 1; HO-1
基因别名: bK286B10; HMOX1; HMOX1D; HO; HO-1; HO1; HSP32
UniProt ID: (Human) P09601
Entrez Gene ID: (Human) 3162
angiogenesis
endothelial cell proliferation
wound healing involved in inflammatory response
negative regulation of leukocyte migration
heme oxidation
cellular iron ion homeostasis
response to oxidative stress
small GTPase mediated signal transduction
excretion
regulation of blood pressure
cell death
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of muscle cell apoptotic process
smooth muscle hyperplasia
cellular response to nutrient
negative regulation of mast cell cytokine production
erythrocyte homeostasis
low-density lipoprotein particle clearance
regulation of transcription from RNA polymerase II promoter in response to iron
cellular response to heat
response to nicotine
intracellular signal transduction
heme catabolic process
response to hydrogen peroxide
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of mast cell degranulation
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of neuron apoptotic process
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
response to estrogen
positive regulation of chemokine biosynthetic process
regulation of angiogenesis
positive regulation of angiogenesis
positive regulation of vasodilation
positive regulation of smooth muscle cell proliferation
negative regulation of smooth muscle cell proliferation
regulation of sequence-specific DNA binding transcription factor activity
protein homooligomerization
iron ion homeostasis
cellular response to arsenic-containing substance
cellular response to cadmium ion
cellular response to hypoxia
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
