Invitrogen

HRG Polyclonal Antibody

查看其他11个HRG抗体

抗体检测数据 (3)

HRG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HRG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HRG Antibody (PA5-79396) in IHC (P)

Immunohistochemistry analysis of HRG on paraffin-embedded human intestinal cancer tissue. Sample was incubated with HRG polyclonal antibody (Product# PA5-79396).

HRG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HRG Antibody in Western Blot (WB)

HRG Antibody in Western Blot (WB)

Product Image Gallery

HRG Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of HRG on paraffin-embedded human intestinal cancer tissue. Sample was incubated with HRG polyclonal antibody (Product# PA5-79396).

HRG Antibody in Western Blot (WB) — Western blot analysis of HRG in recombinant human HRG protein using 0.5 ng per well. Sample was incubated with HRG polyclonal antibody (Product # PA5-79396) at a dilution of 0.5 µg/mL.

HRG Antibody in Western Blot (WB) — Western blot analysis of HRG in human placenta tissue lysate using 50 µg per well. Sample was incubated with HRG (Product # PA5-79396) at a dilution of 0.5 µg/mL.

产品信息

PA5-79396

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL

-

免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E.coli-derived human HRG recombinant protein (Position: V19-V200).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5mg BSA

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2746512

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

靶标信息

HRG contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DKFZp779H1622; Histidine-proline-rich glycoprotein; Histidine-rich glycoprotein; HPRG

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基因别名: HPRG; HRG; HRGP; THPH11

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UniProt ID: (Human) P04196

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Entrez Gene ID: (Human) 3273

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serine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity receptor binding protein binding heparin binding zinc ion binding immunoglobulin binding heme binding heparan sulfate proteoglycan binding metal ion binding protease inhibitor

参与通路

angiogenesis platelet degranulation positive regulation of immune response to tumor cell chemotaxis negative regulation of cell adhesion negative regulation of cell proliferation regulation of gene expression regulation of platelet activation negative regulation of lamellipodium assembly negative regulation of endopeptidase activity heme transport negative regulation of angiogenesis platelet activation regulation of blood coagulation negative regulation of cell growth regulation of actin cytoskeleton organization negative regulation of cell adhesion mediated by integrin fibrinolysis positive regulation of apoptotic process regulation of protein complex assembly negative regulation of blood vessel endothelial cell migration regulation of peptidyl-tyrosine phosphorylation defense response to fungus positive regulation of focal adhesion assembly negative regulation of fibrinolysis negative regulation of vascular endothelial growth factor signaling pathway positive regulation of blood vessel remodeling negative regulation of endothelial cell chemotaxis