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产品信息
PA5-95779
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human HRH3 (NP_0091632)
偶联物
形式
Liquid
浓度
2.87 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807581
产品详细信息
Immunogen sequence: PSPPPPPGCW GCWQKGHGEA MPLHRYGVGE AAVGAEAGEA TLGGGGGGGS VASPTSSSGS SSRGTERPRS LKRGSKPSAS SASLEKRMKM VSQSFTQRFR L; Positive Samples: rat brain; Cellular Location: Cell membrane, Multi-pass membrane protein
靶标信息
H3 Histamine Receptor regulates the release of the neurotransmitters norepinephrine and somatostatin. In histamine-containing neurons of the brain, the H3 receptor acts as a presynaptic autoreceptor, while in nonhistamine-containing neurons, in both the central and peripheral nervous systems, it acts as a presynaptic heteroreceptor. Multiple isoforms of H3 receptors are produced by alternative splicing. Histamine H3 receptor has been reported primarily in brain. ESTs have been isolated from brain (normal and cancer), breast cancer, colon cancer, and retinoblastoma libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G protein-coupled receptor 97; G-protein coupled receptor 97; H3R; HH3R; Histamine H3 receptor; histamine receptor
基因别名: AW049250; GPCR97; H3R; HH3R; HRH3
UniProt ID: (Human) Q9Y5N1, (Rat) Q9QYN8, (Mouse) P58406
Entrez Gene ID: (Human) 11255, (Rat) 85268, (Mouse) 99296
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
neurotransmitter secretion
synaptic transmission, cholinergic
negative regulation of glutamate secretion
regulation of norepinephrine secretion
negative regulation of serotonin secretion
cognition
regulation of neurotransmitter levels
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
brain development
learning
memory
negative regulation of gamma-aminobutyric acid secretion
response to organic cyclic compound
eating behavior
drinking behavior
negative regulation of blood pressure
positive regulation of epithelial cell proliferation
signal transduction
sensory perception of chemical stimulus
