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产品信息
PA5-33851
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 17 amino acid peptide from C-terminus of human HRH4 / Histamine H4 Receptor.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551220
产品详细信息
Percent identity with other species by BLAST analysis: Human (100%) Gibbon, Monkey (94%).
靶标信息
The Histamine H4 receptor has been reported in human blood peripheral leukocytes, bone marrow, colon, liver, lung, smalll intestine, spleen, testis, thymus, tonsil, and trachea. Contrary to the mouse H4 receptor, the human gene was not detected in brain. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AXOR35; G-protein coupled receptor 105; Gprc105; GPRv53; H4R; Histamine H4 receptor; histamine receptor; MGC130500; Pfi-013; SP9144
基因别名: AXOR35; BG26; GPCR105; GPRv53; H4; H4R; HH4R; HRH4
UniProt ID: (Human) Q9H3N8
Entrez Gene ID: (Human) 59340
inflammatory response
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
biological_process
regulation of MAPK cascade
