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HSD11B1 Antibody (PA5-142792) in WB
Western Blot analysis of HSD11B1 in Mouse Lung lysate (60 µg protein in RIPA buffer) using HSD11B1 Polyclonal Antibody (Product # PA5-142792) at 0.3 µg/mL. First lane shows wildtype and second lane shows knockout background. Primary incubation was overnight. Detected by fluorescence with Li-cor. Data obtained from Prof. K. Chapman and Zhenguang Zhang, Centre for Cardiovascular Sciences, Queens Medical Research Institute, Edinburgh, UK.
产品信息
PA5-142792
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-TARSEEGLQKVVSR.
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2933435
产品详细信息
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
靶标信息
HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 11-beta-HSD1; 11-beta-HSD1A/MCR; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase; 11-DH; 11beta-HSD-1; 11beta-HSD1A; 11beta-hydroxysteroid dehydrogenase type 1; 7-oxosteroid reductase; Corticosteroid 11-beta-dehydrogenase isozyme 1; Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A); liver-type 11-beta-HSD; MGC13539; OTTHUMP00000034650
基因别名: Hsd11; Hsd11b1
UniProt ID: (Mouse) P50172
Entrez Gene ID: (Mouse) 15483
