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Invitrogen
HSP27 Recombinant Rabbit Monoclonal Antibody (ARC0531)
高级验证
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
产品信息
MA5-35072
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC0531
抗原
A synthetic peptide corresponding to a sequence within amino acids 100-205 of human HSP27/HSPB1 (P04792)
偶联物
形式
Liquid
浓度
0.09 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2848977
产品详细信息
Immunogen sequence: DVNHFAPDEL TVKTKDGVVE ITGKHEERQD EHGYISRCFT RKYTLPPGVD PTQVSSSLSP EGTLTVEAPM PKLATQSNEI TIPVTFESRA QLGGPEAAKS DETAAK
靶标信息
In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSPB1 (heat shock protein beta-1 or HSP27) is a small heat shock protein which functions as a molecular chaperone that maintains denatured proteins in a folding-competent state. It plays a role in stress resistance and actin organization. Through its molecular chaperone activity, HSP27 regulates numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Mutations in the gene can result in Charcot-Marie-Tooth disease 2F and Neuronopathy distal hereditary motor 2B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 28 kDa heat shock protein; DKFZp586P1322; epididymis secretory protein Li 102; Estrogen-regulated 24 kDa protein; Growth-related 25 kDa protein; Heat shock 25 kDa protein; Heat shock 27 kDa protein; heat shock 27kD protein 1; heat shock 27kDa protein 1; Heat shock protein; Heat shock protein beta-1; Heat shock protein family B member 1; heat shock protein, 25 kDa; HS; HSP; HSP 25; HSP 27; HspB1; p25; Phospho-HSP 27; SRP27; Stress-responsive protein 27; truncated hsp25
基因别名: 27kDa; CMT2F; HEL-S-102; HMN2B; HS.76067; Hsp25; HSP27; HSP28; HSPB1; SRP27
UniProt ID: (Human) P04792, (Mouse) P14602
Entrez Gene ID: (Human) 3315, (Mouse) 15507, (Rat) 24471
negative regulation of protein kinase activity
response to unfolded protein
positive regulation of interleukin-1 beta production
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
positive regulation of tumor necrosis factor biosynthetic process
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of blood vessel endothelial cell migration
positive regulation of angiogenesis
platelet aggregation
negative regulation of protein serine/threonine kinase activity
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of endothelial cell chemotaxis
negative regulation of apoptotic signaling pathway
retina homeostasis
regulation of translational initiation
movement of cell or subcellular component
response to virus
regulation of autophagy
negative regulation of apoptotic process
regulation of mRNA stability
vascular endothelial growth factor receptor signaling pathway
