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Invitrogen
HSP90 Monoclonal Antibody (MBH90AB)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
产品信息
MA1-10372
产品规格
种属反应
Bovine,
Human,
Mouse
已发表种属
Human,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
MBH90AB
抗原
Peptide corresponding to the sequence EEVHHGEEEVEC within N-terminal part of human Hsp90.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11155433
产品详细信息
This antibody recognizes the epitope EEEVE within N-terminal part of ubiquitously expressed Hsp90 alpha and Hsp90 beta intracellular proteins with calculated Mw of 84.7 kDa and 83.3 kDa, respectively, however, migrating as 90 kDa bands under reducing SDS-PAGE conditions.
靶标信息
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; Heat shock 84 kDa; Heat shock 86 kDa; heat shock 90 kDa protein; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein 1, beta; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-beta; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; HSP; HSP 84; HSP 86; HSP 90; HSP86; HSP90-beta; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38; retinal degeneration slow protein; TSTA; Tumor-specific transplantation 84 kDa antigen; Tumor-specific transplantation 86 kDa antigen
基因别名: 86kDa; 89kDa; 90kDa; AL022974; AL024080; AL024147; C81438; D6S182; EL52; HEL-S-65p; hsp4; HSP84; Hsp84-1; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSP90N; HSPC1; HSPC2; HSPC3; HSPCA; HSPCAL1; HSPCAL4; HSPCB; HSPN; LAP-2; LAP2
UniProt ID: (Human) P07900, (Bovine) Q76LV2, (Bovine) Q76LV1, (Human) P08238, (Mouse) P07901, (Mouse) P11499
Entrez Gene ID: (Human) 3320, (Bovine) 281832, (Bovine) 767874, (Human) 3326, (Mouse) 15519, (Mouse) 15516
nucleotide binding
UTP binding
CTP binding
mRNA binding
protein tyrosine kinase activity
protein binding
ATP binding
GTP binding
ATPase activity
sulfonylurea receptor binding
protein kinase binding
protein phosphatase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
TPR domain binding
dATP binding
identical protein binding
protein homodimerization activity
histone deacetylase binding
ion channel binding
poly(A) RNA binding
GTPase binding
Rho GDP-dissociation inhibitor binding
unfolded protein binding
disordered domain specific binding
double-stranded RNA binding
protein kinase regulator activity
heat shock protein binding
ubiquitin protein ligase binding
peptide binding
ATP-dependent protein binding
protein binding involved in protein folding
protein dimerization activity
tau protein binding
DNA polymerase binding
histone methyltransferase binding
kinase binding
cadherin binding involved in cell-cell adhesion
Hsp90 family chaperone
G2/M transition of mitotic cell cycle
neuron migration
skeletal muscle contraction
mitochondrial transport
receptor-mediated endocytosis
response to unfolded protein
signal transduction
response to heat
response to cold
response to salt stress
positive regulation of lamellipodium assembly
cardiac muscle cell apoptotic process
peptidyl-tyrosine phosphorylation
regulation of protein ubiquitination
positive regulation of protein import into nucleus, translocation
Fc-gamma receptor signaling pathway involved in phagocytosis
ERBB2 signaling pathway
protein refolding
regulation of protein complex assembly
protein unfolding
response to estrogen
protein import into mitochondrial outer membrane
positive regulation of nitric oxide biosynthetic process
positive regulation of cell size
response to antibiotic
vascular endothelial growth factor receptor signaling pathway
protein stabilization
regulation of nitric-oxide synthase activity
chaperone-mediated protein complex assembly
positive regulation of cardiac muscle contraction
chaperone-mediated autophagy
regulation of cellular response to heat
regulation of catalytic activity
placenta development
telomere maintenance via telomerase
virion attachment to host cell
central nervous system neuron axonogenesis
establishment of cell polarity
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of phosphoprotein phosphatase activity
positive regulation of peptidyl-serine phosphorylation
negative regulation of apoptotic process
positive regulation of cell differentiation
axon extension
positive regulation of protein kinase B signaling
positive regulation of telomerase activity
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
negative regulation of cell cycle arrest
cellular response to interleukin-4
fibril organization
negative regulation of transforming growth factor beta activation
positive regulation of cyclin-dependent protein kinase activity
telomerase holoenzyme complex assembly
positive regulation of protein localization to cell surface
protein folding
positive regulation of protein binding
negative regulation of neuron apoptotic process
cellular response to organic cyclic compound
positive regulation of protein serine/threonine kinase activity
cell-cell adhesion
nitric oxide biosynthetic process
response to stress
positive regulation of cytotoxic T cell differentiation
