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Invitrogen
HSP90 beta Monoclonal Antibody (H90-10)
高级验证
This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated.
图: 1 / 5
HSP90 beta Antibody (MA1-10892) in ICC/IF
Immunofluorescence analysis of HSP90 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with HSP90 Monoclonal Antibody(H90-10) (Product # MA1-10892) at 5µg/mL in 0.1% BSA and incubated overnight at 4 degree and... View More
产品信息
MA1-10892
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rabbit
已发表种属
Human,
Mouse
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
H90-10
抗原
Purified human Hsp90 beta.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_906421
产品详细信息
MA1-10892 detects 90 kDa Hsp90 beta in all reactive species except chicken where it detects both alpha and beta isoforms.
MA1-10892 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, MA1-10892 is specific for the ~90 kDa Heat Shock Protein 90 protein.
MA1-10892 immunogen is purified human Hsp90 beta.
靶标信息
Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Heat shock 84 kDa; heat shock 90kD protein 1, beta; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-beta; heat shock protein, 84 kDa 1; HSP; HSP 84; HSP 90; HSP90-beta; retinal degeneration slow protein; RP1-302G2.1; TSTA; Tumor-specific transplantation 84 kDa antigen
基因别名: 90kDa; AL022974; C81438; D6S182; HSP84; Hsp84-1; Hsp90; HSP90AB1; HSP90B; HSPC2; HSPC3; HSPCB
UniProt ID: (Rabbit) P30947, (Human) P08238, (Mouse) P11499
Entrez Gene ID: (Rabbit) 100358690, (Human) 3326, (Mouse) 15516
UTP binding
CTP binding
double-stranded RNA binding
protein binding
ATP binding
GTP binding
sulfonylurea receptor binding
protein kinase regulator activity
kinase binding
protein kinase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
TPR domain binding
dATP binding
histone deacetylase binding
ion channel binding
poly(A) RNA binding
unfolded protein binding
cadherin binding involved in cell-cell adhesion
nucleotide binding
Hsp90 family chaperone
placenta development
protein folding
response to unfolded protein
response to salt stress
virion attachment to host cell
regulation of protein ubiquitination
positive regulation of protein binding
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of phosphoprotein phosphatase activity
positive regulation of protein import into nucleus, translocation
Fc-gamma receptor signaling pathway involved in phagocytosis
negative regulation of neuron apoptotic process
positive regulation of nitric oxide biosynthetic process
positive regulation of cell size
protein stabilization
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
cellular response to interleukin-4
cellular response to organic cyclic compound
positive regulation of protein serine/threonine kinase activity
fibril organization
cell-cell adhesion
regulation of cellular response to heat
response to stress
