Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-83344
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Anitgen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2790500
产品详细信息
Immunogen sequence: GSDANTYANL CQLRAASRRS ERLHRPPVIV LQRGACGQGQ EDPNSLRHKY NFIA
靶标信息
HtrA1, a 51KDa protein, is a member of highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and consists of a secretory signal sequence, an IGFBP-binding domain and a Kazal-type serine-protease inhibitor domain at the N-terminus and a highly conserved trypsin-like serine/protease domain and a PDZ domain at the C-terminus. It plays a major role in the regulation of cell growth. HtrA1 inhibits signaling mediated by TGF-beta family members and regulates many physiological processes. HtrA1 is up-regulated in placenta during pregnancy and plays an important role in implantation and placental physiology. It regulates the availability of IGFs by cleaving IGF-binding proteins. It acts as a tumor suppressor and is down-regulated in ovarian cancers and melanomas. Its role has been implicated in osteoarthritis suggesting a therapeutic intervention. Northern blot analysis detected high expression in placenta.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: High-temperature requirement A serine peptidase 1; IGFBP5-protease; L56; protease, serine, 11 (IGF binding); Serine protease 11; Serine protease HTRA1
基因别名: ARMD7; CADASIL2; CARASIL; HTRA; HTRA1; L56; ORF480; PRSS11
UniProt ID: (Human) Q92743
Entrez Gene ID: (Human) 5654
regulation of cell growth
placenta development
proteolysis
extracellular matrix disassembly
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
positive regulation of epithelial cell proliferation
negative regulation of defense response to virus
chorionic trophoblast cell differentiation
dentinogenesis
