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HtrA3 belongs to the human high-temperature requirement factor A (HtrA) family. It is also called pregnancy-related serine protease. HtrA3 has two isoforms (long and short), which is produced by alternative splicing. Similar to HtrA1, HtrA3 binds to various TGF-beta proteins and inhibited the signaling of BMP-4, -2 and TGF-beta 1. HtrA3 does not inhibit signaling originated from a constitutively active BMP receptor, indicating that the inhibition occurred upstream of the cell surface receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: High-temperature requirement factor A3; Pregnancy-related serine protease; probable serine protease HTRA3; Serine protease HTRA3; Toll-associated serine protease
基因别名: 2210021K23Rik; 9530081K03Rik; HTRA3; PRSP; RGD1308120; Tasp
UniProt ID: (Human) P83110, (Mouse) Q9D236, (Rat) D3ZA76
Entrez Gene ID: (Human) 94031, (Mouse) 78558, (Rat) 360959
分子生物学功能: serine protease