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产品信息
H00008692-B02P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
HYAL2 (ABM84764.1, 1 a.a. approximately 473 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MRAGPGPTVT LALVLAVAWA MELKPTAPPI FTGRPFVVAW DVPTQDCGPR LKVPLDLNAF DVQASPNEGF VNQNITIFYR DRLGLYPRFD SAGRSVHGGV PQNVSLWAHR KMLQKRVEHY IRTQESAGLA VIDWEDWRPV WVRNWQDKDV YRRLSRQLVA SRHPDWPPDR IVKQAQYEFE FAAQQFMLET LRYVKAVRPR HLWGFYLFPD CYNHDYVQNW ESYTGRCPDV EVARNDQLAW LWAESTALFP SVYLDETLAS SRHGRNFVSF RVQEALRVAR THHANHALPV YVFTRPTYSR RLTGLSEMDL ISTIGESAAL GAAGVILWGD AGYTTSTETC QYLKDYLTRL LVPYVVNVSW ATQYCSRAQC HGHGRCVRRN PSASTFLHLS TNSFRLVPGH APGEPQLRPV GELSWADIDH LQTHFRCQCY LGWSGEQCQW DHRQAAGGAS EAWAGSHLTS LLALAALAFT WTL
靶标信息
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Hyal-2; hyaluronidase 2; Hyaluronidase-2; Hyaluronoglucosaminidase-2; LuCa-2; Lung carcinoma protein 2; lysosomal hyaluronidase; PH-20 homolog; PH20 homolog
基因别名: HYAL2; LUCA2
UniProt ID: (Human) Q12891
Entrez Gene ID: (Human) 8692
RNA polymerase II transcription coactivator activity
virus receptor activity
hyalurononglucosaminidase activity
protein binding
hyaluronic acid binding
enzyme binding
receptor signaling protein tyrosine kinase inhibitor activity
receptor tyrosine kinase binding
hyaluronoglucuronidase activity
transforming growth factor beta binding
glycosidase
response to reactive oxygen species
kidney development
hematopoietic progenitor cell differentiation
carbohydrate metabolic process
glycosaminoglycan catabolic process
response to virus
multicellular organism aging
negative regulation of fibroblast migration
fusion of virus membrane with host plasma membrane
transformation of host cell by virus
hyaluronan catabolic process
negative regulation of cell growth
positive regulation of urine volume
monocyte activation
positive regulation of protein import into nucleus
negative regulation of MAP kinase activity
cellular response to fibroblast growth factor stimulus
positive regulation of transcription from RNA polymerase II promoter
response to antibiotic
viral entry into host cell
skeletal system morphogenesis
positive regulation of inflammatory response
cartilage development
defense response to virus
negative regulation of protein kinase B signaling
multicellular organismal iron ion homeostasis
negative regulation of protein tyrosine kinase activity
renal water absorption
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to UV-B
cellular response to transforming growth factor beta stimulus
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion
positive regulation of extrinsic apoptotic signaling pathway
