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Histamine H1 Receptor/HRH1 (extracellular) Antibody (AHR-006-200UL) in IHC (F)
Expression of Histamine H1Receptor in mouse substantia nigra - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-Histamine H1 Receptor/HRH1 Antibody (extracellular) (#AHR-006), (1:300), followed by goat Anti-rabbit-AlexaFluor-488. A. Histamine H1Receptor immunoreactivity (green) appears in neuronal profiles (vertical arrows). B. Pre-incubation of the Antibody with Histami... View More
产品信息
AHR-006-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)REDK(S)ETDFYNVTWFK, corresponding to amino acid residues 176-191 of mouse H1 Histamine Receptor, 2ndextracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bordetella pertussis induced histamine sensitization; H1 receptor; H1-R; H1R; HH1R; Histamine H1 receptor; Histamine H1-R; histamine receptor; histamine receptor, subclass H1
基因别名: Bphs; H1-R; H1R; HH1R; Hir; hisH1; Hisr; HRH1
UniProt ID: (Human) P35367, (Mouse) P70174, (Rat) P31390
Entrez Gene ID: (Human) 3269, (Mouse) 15465, (Rat) 24448
inflammatory response
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
memory
visual learning
regulation of vasoconstriction
positive regulation of inositol trisphosphate biosynthetic process
regulation of vascular permeability
positive regulation of vasoconstriction
inositol phosphate-mediated signaling
regulation of synaptic plasticity
eosinophil chemotaxis
modulation of synaptic transmission
cellular response to histamine
signal transduction
chemical synaptic transmission
sensory perception of chemical stimulus
negative regulation of steroid biosynthetic process
positive regulation of nitric oxide biosynthetic process
rhythmic process
calcium ion import
calcium ion transmembrane transport
manganese ion transmembrane transport
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
response to gravity
