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产品信息
MA5-17095
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
4E12G5
抗原
Purified recombinant fragment of human ID2 (amino acids: 1-134) expressed in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2538566
产品详细信息
MA5-17095 targets ID2 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples.
The MA5-17095 immunogen is purified recombinant fragment of human ID2 (amino acids: 1-134) expressed in E. Coli.
MA5-17095 detects ID2 which has a predicted molecular weight of approximately 15kDa.
靶标信息
The inhibitor of DNA binding 2 (ID2) protein is essential for promoting the development of a number of cell types including natural killer cell, erythroid precursors, as well as, CD8+ and CD4+ T-cell. A lack of ID2 promotes B-cell development. The chief role of this protein is to associate with ubiquitously-expressed E proteins, and other proteins of the basic helix-loop-helix (HLH) family, preventing them from binding to DNA and activating transcription. Activation of ID2 is critical for the development of the natural killer cell lineage.
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生物信息学
蛋白别名: bHLHb26; cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; helix-loop-helix protein ID2; Inhibitor of differentiation 2; Inhibitor of DNA binding 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; MGC26389; OTTHUMP00000140258; OTTHUMP00000200297
基因别名: BHLHB26; GIG8; ID2; ID2A; ID2H
UniProt ID: (Human) Q02363
Entrez Gene ID: (Human) 3398
negative regulation of transcription from RNA polymerase II promoter
metanephros development
natural killer cell differentiation
thigmotaxis
membranous septum morphogenesis
bundle of His development
transcription, DNA-templated
multicellular organism development
adult locomotory behavior
positive regulation of gene expression
negative regulation of gene expression
oligodendrocyte development
regulation of lipid metabolic process
olfactory bulb development
circadian regulation of gene expression
mammary gland epithelial cell proliferation
regulation of circadian rhythm
entrainment of circadian clock by photoperiod
enucleate erythrocyte differentiation
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
locomotor rhythm
negative regulation of B cell differentiation
positive regulation of fat cell differentiation
positive regulation of erythrocyte differentiation
positive regulation of macrophage differentiation
negative regulation of neuron differentiation
negative regulation of osteoblast differentiation
positive regulation of blood pressure
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
cell maturation
Peyer's patch development
embryonic digestive tract morphogenesis
positive regulation of smooth muscle cell proliferation
neuron fate commitment
cell morphogenesis involved in neuron differentiation
positive regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
adipose tissue development
mammary gland alveolus development
epithelial cell differentiation involved in mammary gland alveolus development
endodermal digestive tract morphogenesis
positive regulation of cell cycle arrest
cellular response to lithium ion
positive regulation of transcription involved in G1/S transition of mitotic cell cycle
cellular senescence
regulation of G1/S transition of mitotic cell cycle
negative regulation of neural precursor cell proliferation
