Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
ID2 Monoclonal Antibody (K.79.0)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
图: 1 / 4
ID2 Antibody (MA5-14777) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of HT-29 (Lane 1), SW480 (Lane 2), SK-OV-3 (Lane 3), SH-SY5Y (Lane 4) and SH-SY5Y treated with Retinoic acid (10 uM for 6 days) (Lane 5). The blot was probed with Anti-ID2 Monoclonal Antibody (Product # MA5-14777, 1:500 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 14 kDa band corresponding to ID2 was observed across the cell lines ... View More
产品信息
MA5-14777
产品规格
种属反应
Human,
Mouse,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
K.79.0
抗原
Synthetic peptide corresponding to residues surrounding Asn97 of human Id2 protein
偶联物
形式
Liquid
浓度
118 µg/mL
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
<0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_10980445
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
The inhibitor of DNA binding 2 (ID2) protein is essential for promoting the development of a number of cell types including natural killer cell, erythroid precursors, as well as, CD8+ and CD4+ T-cell. A lack of ID2 promotes B-cell development. The chief role of this protein is to associate with ubiquitously-expressed E proteins, and other proteins of the basic helix-loop-helix (HLH) family, preventing them from binding to DNA and activating transcription. Activation of ID2 is critical for the development of the natural killer cell lineage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: bHLHb26; cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; helix-loop-helix protein ID2; Inhibitor of differentiation 2; Inhibitor of DNA binding 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; MGC26389; OTTHUMP00000140258; OTTHUMP00000200297
基因别名: AI255428; BHLHB26; C78922; GIG8; Id-2; ID2; ID2A; ID2H; Idb2
UniProt ID: (Human) Q02363, (Mouse) P41136
Entrez Gene ID: (Human) 3398, (Mouse) 15902
negative regulation of transcription from RNA polymerase II promoter
metanephros development
natural killer cell differentiation
thigmotaxis
membranous septum morphogenesis
bundle of His development
transcription, DNA-templated
multicellular organism development
adult locomotory behavior
positive regulation of gene expression
negative regulation of gene expression
oligodendrocyte development
regulation of lipid metabolic process
olfactory bulb development
circadian regulation of gene expression
mammary gland epithelial cell proliferation
regulation of circadian rhythm
entrainment of circadian clock by photoperiod
enucleate erythrocyte differentiation
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
locomotor rhythm
negative regulation of B cell differentiation
positive regulation of fat cell differentiation
positive regulation of erythrocyte differentiation
positive regulation of macrophage differentiation
negative regulation of neuron differentiation
negative regulation of osteoblast differentiation
positive regulation of blood pressure
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
cell maturation
Peyer's patch development
embryonic digestive tract morphogenesis
positive regulation of smooth muscle cell proliferation
neuron fate commitment
cell morphogenesis involved in neuron differentiation
positive regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
adipose tissue development
mammary gland alveolus development
epithelial cell differentiation involved in mammary gland alveolus development
endodermal digestive tract morphogenesis
positive regulation of cell cycle arrest
cellular response to lithium ion
positive regulation of transcription involved in G1/S transition of mitotic cell cycle
cellular senescence
regulation of G1/S transition of mitotic cell cycle
negative regulation of neural precursor cell proliferation
leukocyte differentiation
regulation of transcription, DNA-templated
heart development
positive regulation of cell proliferation
entrainment of circadian clock
positive regulation of cell cycle
cell development
rhythmic process
lymph node development
