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Product Details
PA5-31381
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 667 and 883 of Human IFT122
Conjugate
Unconjugated
Form
Liquid
Concentration
0.95 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2548855
Product Specific Information
Recommended positive controls: 293T.
Predicted reactivity: Mouse (84%), Rat (84%), Bovine (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: intraflagellar transport 122 homolog; Intraflagellar transport protein 122 homolog; WD repeat domain 10; WD repeat-containing protein 10; WD repeat-containing protein 140
Gene Aliases: CED; CED1; IFT122; SPG; WDR10; WDR10p; WDR140; zgc:77217
UniProt ID: (Human) Q9HBG6, (Zebrafish) Q6NYH1
Entrez Gene ID: (Human) 55764, (Zebrafish) 405826
mesonephros development
multicellular organism development
heart development
regulation of smoothened signaling pathway
photoreceptor cell morphogenesis
cell projection organization
melanosome transport
intraciliary retrograde transport
opsin transport
intraciliary transport
photoreceptor cell maintenance
negative regulation of smoothened signaling pathway
camera-type eye morphogenesis
cilium morphogenesis
protein localization to cilium
non-motile cilium assembly
neural tube closure
signal transduction downstream of smoothened
embryonic body morphogenesis
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
embryonic heart tube development
embryonic forelimb morphogenesis
intraciliary anterograde transport
intraciliary transport involved in cilium morphogenesis
cilium assembly
embryonic digit morphogenesis
negative regulation of epithelial cell proliferation
limb development
ciliary receptor clustering involved in smoothened signaling pathway
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
embryonic heart tube left/right pattern formation
establishment of protein localization to organelle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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