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产品信息
PA1-4162
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues R(385) R S P P E E P P D F C C P K(399) of human IKK gamma.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_559596
产品详细信息
PA1-4162 detects IKK gamma in human samples. This antibody recognizes both human IKK gamma isoforms.
PA1-4162 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~50 kDa protein representing the IKK gamma protein in Interleukin-1-stimulated 293 cells.
The PA1-4162 immunogen is a synthetic peptide corresponding to residues R(385) R S P P E E P P D F C C P K(399) of human IKK gamma.
靶标信息
IKK gamma is the regulatory subunit of the inhibitor of the kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FIP-3; gikk; I-kappa-B kinase subunit gamma; ikB kinase subunit gamma; IkB kinase-associated protein 1; IKK3; IKKAP1; incontinentia pigmenti; Inhibitor of nuclear factor kappa-B kinase subunit gamma; mF; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; OTTHUMP00000207079; OTTHUMP00000212188
基因别名: AMCBX1; FIP-3; FIP3; Fip3p; IKBKG; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
UniProt ID: (Human) Q9Y6K9
Entrez Gene ID: (Human) 8517
signal transducer activity
protein binding
protein domain specific binding
ubiquitin protein ligase binding
protein homodimerization activity
peroxisome proliferator activated receptor binding
metal ion binding
protein heterodimerization activity
K63-linked polyubiquitin binding
linear polyubiquitin binding
activation of MAPK activity
stimulatory C-type lectin receptor signaling pathway
transcription, DNA-templated
apoptotic process
inflammatory response
immune response
cellular response to DNA damage stimulus
I-kappaB kinase/NF-kappaB signaling
JNK cascade
response to virus
regulation of tumor necrosis factor-mediated signaling pathway
TRIF-dependent toll-like receptor signaling pathway
Fc-epsilon receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of transcription from RNA polymerase II promoter
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
establishment of vesicle localization
nucleotide-binding oligomerization domain containing signaling pathway
negative regulation of neuron death
