Invitrogen

IKK gamma Polyclonal Antibody

高级验证

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

查看其他23个IKK gamma抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

IKK gamma Antibody in Immunocytochemistry (ICC/IF)

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IKK gamma Antibody (PA5-120057) in ICC/IF

Immunofluorescence analysis of Ikbkg was performed using 80% confluent log phase HEK-293 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with IKK gamma Polyclonal Antibody (Product # PA5-120057, 1:100) in 0.1% BSA, incubated at 4 degree celsius overnig... View More

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产品信息

PA5-120057

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:50-1:100

免疫细胞化学 (ICC/IF)

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 250-390 of human IKK gamma (NP_0036301)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.58 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2913629

产品详细信息

Positive test controls include: HeLa, Jurkat, Mouse brain, Rat brain. The target is usually found in the following locations: Cytoplasm, Nucleus.

Immunogen sequence: VGSERKRGMQ LEDLKQQLQQ AEEALVAKQE VIDKLKEEAE QHKIVMETVP VLKAQADIYK ADFQAERQAR EKLAEKKELL QEQLEQLQRE YSKLKASCQE SARIEDMRKR HVEVSQAPLP PAPAYLSSPL ALPSQRRSPP E

靶标信息

IKK gamma is the regulatory subunit of the inhibitor of the kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: FIP-3; gikk; I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; ikB kinase subunit gamma; IkB kinase-associated protein 1; IKK-gamma; IKK3; IKKAP1; IKKG; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of kappaB kinase gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; mF; mFIP-3; NEMO; NF-kappa B essential modulator; NF-kappa-B essential modifier; NF-kappa-B essential modulator; OTTHUMP00000207079; OTTHUMP00000212188

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基因别名: 1110037D23Rik; AI848108; AI851264; AMCBX1; AW124339; FIP-3; FIP3; Fip3p; IKBKG; IKK-gamma; IKK[g]; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9

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UniProt ID: (Human) Q9Y6K9, (Mouse) O88522, (Rat) Q6TMG5

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Entrez Gene ID: (Human) 8517, (Mouse) 16151, (Rat) 309295

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功能

signal transducer activity protein binding protein domain specific binding ubiquitin protein ligase binding protein homodimerization activity peroxisome proliferator activated receptor binding metal ion binding protein heterodimerization activity K63-linked polyubiquitin binding linear polyubiquitin binding

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