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产品信息
PA5-79498
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived rat IL-3 recombinant protein (Position: S28-C166).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746614
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Interleukin 3 (IL-3), also called Mast Cell Growth Factor (MCGF), Multi-Colony Stimulating Factor (multi-CSF), or Eosinophil-CSF (E-CSF), is produced by activated T cells, mast cells and eosinophils. IL-3 is a hematopoietic growth factor that stimulates colony formation of erythroid, megakaryocyte, neutrophil, eosinophil, basophil, mast cell and monocytic lineages. Most of these functions are enhanced or dependent on co-stimulation with other cytokines. Human and mouse IL-3 share only 29% sequence identity at the amino acid level. The bioactivity of IL-3 is highly species specific. For example, human IL-3 has no activity on mouse cells. IL-3 is a potent growth promoting cytokine. IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types, and is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BP/BPA; Colony stimulating factor multiple; Eo-CSF; hematopoietic growth factor; IL-3; ILN; Interleukin; Interleukin 3 (colony stimulating factor; interleukin-3; Interleukin3; mast cell growth factor; MCGF; MGC79398; MGC79399; Multi CSF; Multilineage colony stimulating factor; multiple); multipotential colony-stimulating factor; P cell stimulating factor; P-cell-stimulating factor; PCSA
Entrez Gene ID: (Rat) 24495
regulation of cell growth
response to hypoxia
positive regulation of protein phosphorylation
positive regulation of myeloid leukocyte differentiation
regulation of glycolytic process
immune response
positive regulation of cell proliferation
response to hormone
regulation of gene expression
negative regulation of autophagy
cytokine-mediated signaling pathway
hemopoiesis
negative regulation of mast cell apoptotic process
myeloid cell apoptotic process
embryonic hemopoiesis
regulation of protein dephosphorylation
positive regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of apoptotic process
positive regulation of DNA replication
positive regulation of JNK cascade
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of mast cell proliferation
extrinsic apoptotic signaling pathway in absence of ligand
