Invitrogen

IL-4 Polyclonal Antibody

IL-4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IL-4 Antibody (PA5-25165) in IHC (P)

Immunohistochemistry analysis of IL-4 in formalin fixed and paraffin embedded tonsil. Samples were incubated with IL-4 polyclonal antibody (Product # PA5-25165) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.

IL-4 Antibody in Immunohistochemistry (IHC)

IL-4 Antibody in Immunohistochemistry, Immunohistochemistry (Paraffin) (IHC, IHC (P))

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产品信息

PA5-25165

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

查看2篇已发表文章 2篇已发表文章

免疫组化 (IHC)

查看9篇已发表文章 9篇已发表文章

免疫组化（石蜡） (IHC (P))

1:10-1:50

查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

1:10-1:50

产品规格

种属反应

Human, Mouse

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 122-150 amino acids from the C-terminal region of human L4

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2 mg/mL

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2542665

产品详细信息

This antibody is predicted to react with non-human primate based on sequence homology.

靶标信息

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

A novel transgenic mouse model expressing primate-specific nuclear choline acetyltransferase: insights into potential cholinergic vulnerability.

Scientific reports

AlQot HE,Rylett RJ

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Western Blot

Tue Feb 21 00:00:00 EST 2023

A novel transgenic mouse model expressing primate-specific nuclear choline acetyltransferase: insights into potential cholinergic vulnerability.

Scientific reports

AlQot HE,Rylett RJ

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Western Blot

Tue Feb 21 00:00:00 EST 2023

Establishment of a humanized mouse model of keloid diseases following the migration of patient immune cells to the lesion: Patient-derived keloid xenograft (PDKX) model.

Experimental & molecular medicine

Lee AR,Lee SY,Choi JW,Um IG,Na HS,Lee JH,Cho ML

PA5-25165 was used in Immunohistochemistry to develop the patient-derived keloid xenograft (PDKX), which is a humanized mouse model, and compared it to the traditional mouse xenograft model (transplantation of only keloid lesions).

Tue Aug 01 00:00:00 EDT 2023

Calf Thymus Polypeptide Restrains the Growth of Colorectal Tumor via Regulating the Intestinal Microbiota-Mediated Immune Function.

Frontiers in pharmacology

Li L,Zhao C,Kong F,Li YC,Wang C,Chen S,Tan HY,Liu Y,Wang D

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Sat Jul 16 00:00:00 EDT 2022

Brain-derived CCR5 Contributes to Neuroprotection and Brain Repair after Experimental Stroke.

Aging and disease

Ping S,Qiu X,Kyle M,Zhao LR

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Mon Feb 01 00:00:00 EST 2021

Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B.

Cells

Vallecillo-Zúniga ML,Poulson PD,Luddington JS,Arnold CJ,Rathgeber M,Kartchner BC,Hayes S,Gill H,Valdoz JC,Spallino JL,Garfield S,Dodson EL,Arthur CM,Stowell SR,Van Ry PM

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Western Blot

Wed Nov 17 00:00:00 EST 2021

Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B.

Cells

Vallecillo-Zúniga ML,Poulson PD,Luddington JS,Arnold CJ,Rathgeber M,Kartchner BC,Hayes S,Gill H,Valdoz JC,Spallino JL,Garfield S,Dodson EL,Arthur CM,Stowell SR,Van Ry PM

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Western Blot

Wed Nov 17 00:00:00 EST 2021

Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice.

Aging and disease

Guo X,Liu Y,Morgan D,Zhao LR

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Tue Dec 01 00:00:00 EST 2020

Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice.

Aging and disease

Guo X,Liu Y,Morgan D,Zhao LR

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Tue Dec 01 00:00:00 EST 2020

Renal expression of cytokines and chemokines in diabetic nephropathy.

BMC nephrology

Araújo LS,Torquato BGS,da Silva CA,Dos Reis Monteiro MLG,Dos Santos Martins ALM,da Silva MV,Dos Reis MA,Machado JR

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Tue Jul 28 00:00:00 EDT 2020

Renal expression of cytokines and chemokines in diabetic nephropathy.

BMC nephrology

Araújo LS,Torquato BGS,da Silva CA,Dos Reis Monteiro MLG,Dos Santos Martins ALM,da Silva MV,Dos Reis MA,Machado JR

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Tue Jul 28 00:00:00 EDT 2020

IL-4/IL-13 remodeling pathway of COVID-19 lung injury.

Scientific reports

Vaz de Paula CB,de Azevedo MLV,Nagashima S,Martins APC,Malaquias MAS,Miggiolaro AFRDS,da Silva Motta Júnior J,Avelino G,do Carmo LAP,Carstens LB,de Noronha L

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Thu Oct 29 00:00:00 EDT 2020

IL-4/IL-13 remodeling pathway of COVID-19 lung injury.

Scientific reports

Vaz de Paula CB,de Azevedo MLV,Nagashima S,Martins APC,Malaquias MAS,Miggiolaro AFRDS,da Silva Motta Júnior J,Avelino G,do Carmo LAP,Carstens LB,de Noronha L

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Thu Oct 29 00:00:00 EDT 2020

Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis.

Frontiers in immunology

Motta Junior JDS,Miggiolaro AFRDS,Nagashima S,de Paula CBV,Baena CP,Scharfstein J,de Noronha L

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Mon Oct 26 00:00:00 EDT 2020

Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis.

Frontiers in immunology

Motta Junior JDS,Miggiolaro AFRDS,Nagashima S,de Paula CBV,Baena CP,Scharfstein J,de Noronha L

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Mon Oct 26 00:00:00 EDT 2020

STAT6 deficiency ameliorates Graves' disease severity by suppressing thyroid epithelial cell hyperplasia.

Cell death & disease

Jiang X,Zha B,Liu X,Liu R,Liu J,Huang E,Qian T,Liu J,Wang Z,Zhang D,Wang L,Chu Y

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Thu Dec 01 00:00:00 EST 2016

STAT6 deficiency ameliorates Graves' disease severity by suppressing thyroid epithelial cell hyperplasia.

Cell death & disease

Jiang X,Zha B,Liu X,Liu R,Liu J,Huang E,Qian T,Liu J,Wang Z,Zhang D,Wang L,Chu Y

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunohistochemistry

Thu Dec 01 00:00:00 EST 2016

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds.

Biomaterials

Spiller KL,Nassiri S,Witherel CE,Anfang RR,Ng J,Nakazawa KR,Yu T,Vunjak-Novakovic G

Published figure using IL-4 polyclonal antibody (Product # PA5-25165) in Immunofluorescence

Thu Jan 01 00:00:00 EST 2015

生物信息学

蛋白别名: B cell growth factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; B_cell stimulatory factor 1; Binetrakin; BSF-1; H-IL-4; IGG1 induction factor; IL-4; ILN; Interleukin; interleukin 4 variant 2; Interleukin-4; Interleukin4; Lymphocyte stimulatory factor 1; M-IL-4; MGC79402; Pitrakinra

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基因别名: BCGF-1; BCGF1; BSF-1; BSF1; IL-4; IL4

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UniProt ID: (Human) P05112, (Mouse) P07750

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Entrez Gene ID: (Human) 3565, (Mouse) 16189

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功能

cytokine activity interleukin-4 receptor binding protein binding growth factor activity cytokine receptor binding interleukin superfamily

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