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产品信息
PA5-34571
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
An 18 amino acid peptide near the amino terminus of human IL-17RA
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551923
产品详细信息
A suggested positive control is A-20 cell lysate.
PA5-34571 can be used with blocking peptide PEP-1614.
靶标信息
Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F. IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD217; CDw217; IL-17 receptor A; IL-17RA; Interleukin-17 receptor A; MGC10262
基因别名: AW538159; CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R; IL17RA; VDw217
UniProt ID: (Human) Q96F46, (Mouse) Q60943
Entrez Gene ID: (Human) 23765, (Rat) 312679, (Mouse) 16172
cell surface receptor signaling pathway
cytokine-mediated signaling pathway
positive regulation of interleukin-23 production
defense response to fungus
granulocyte chemotaxis
fibroblast activation
positive regulation of cytokine production involved in inflammatory response
positive regulation of interleukin-5 secretion
positive regulation of interleukin-13 secretion
cellular response to cytokine stimulus
