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IL17RA Antibody (MA5-46698) in Flow
Flow cytometry analysis of IL17RA in human whole blood granulocytes using IL17RA, FITC Recombinant Monoclonal (Product # MA5-46698). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes.
产品信息
MA5-46698
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
004
抗原
Recombinant protein ecoding Human IL17RA (Met1-Trp320).
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
100 µg/mL
纯化类型
Protein A
保存液
PBS with 0.5% BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2937770
产品详细信息
Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human IL17RA (Met1-Trp320) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
靶标信息
Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F. IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD217; CDw217; IL-17 receptor A; Interleukin-17 receptor A; MGC10262
基因别名: CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R; IL17RA
UniProt ID: (Human) Q96F46
Entrez Gene ID: (Human) 23765
cell surface receptor signaling pathway
cytokine-mediated signaling pathway
positive regulation of interleukin-23 production
defense response to fungus
granulocyte chemotaxis
fibroblast activation
positive regulation of cytokine production involved in inflammatory response
positive regulation of interleukin-5 secretion
positive regulation of interleukin-13 secretion
