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IL24 Antibody (MA5-24013) in ICC/IF
Immunocytochemistry analysis of IL24 in immersion fixed mouse splenocytes. Samples were incubated in IL24 monoclonal antibody (Product # MA5-24013) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm.
产品信息
MA5-24013
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
303308
抗原
E. coli-derived recombinant mouse IL-24 Arg27-His181
偶联物
Unconjugated
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2606278
产品详细信息
No cross-reactivity with recombinant human IL-24 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Interleukin 24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) encodes a secreted protein that exhibits significant homology to the interleukin 10 (IL-10) family of cytokines. The human IL-24 is secreted by activated peripheral blood mononuclear cells and binds two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 resulting in the activation of JAK/STAT signaling pathways. Mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IL 24; IL-24; IL-4-induced secreted protein; Interleukin; Interleukin-24; MDA-7; Melanoma differentiation-associated gene 7 protein; Th2-specific cytokine FISP
基因别名: FISP; Il24; Mda-7; Mda7; St16
UniProt ID: (Mouse) Q925S4
Entrez Gene ID: (Mouse) 93672
apoptotic process
inflammatory response
immune response
positive regulation of cell proliferation
negative regulation of cell proliferation
negative regulation of cell migration
serine phosphorylation of STAT3 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of JAK-STAT cascade
