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产品信息
A302-661A-T
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Between 270 and 320
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Impact homolog; Imprinted and ancient gene protein homolog; Protein IMPACT; RWD domain containing 5
基因别名: IMPACT; RWDD5
UniProt ID: (Human) Q9P2X3
Entrez Gene ID: (Human) 55364
negative regulation of transcription from RNA polymerase II promoter
negative regulation of protein phosphorylation
biological_process
negative regulation of protein complex assembly
negative regulation of protein autophosphorylation
cellular response to amino acid starvation
cellular response to glucose starvation
positive regulation of neuron differentiation
negative regulation of cell death
regulation of eIF2 alpha phosphorylation by amino acid starvation
cellular response to hydrogen peroxide
positive regulation of translational initiation in response to starvation
cellular response to acidic pH
cellular response to UV-C
cellular response to benomyl
negative regulation of transcription from RNA polymerase II promoter in response to stress
neuron projection extension
cellular response to leucine starvation
