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INSIG1 Antibody (MA5-55473) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Rat liver using INSIG1 Recombinant Monoclonal Antibody (Product # MA5-55473) at a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Buffer (pH 6. 0) prior to IHC staining.
产品信息
MA5-55473
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
0Q2B5
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 177-277 of human INSIG1.
偶联物
形式
Liquid
浓度
1.19 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
产品详细信息
Immunogen Sequence: ASAKLDFANN VQLSLTLAAL SLGLWWTFDR SRSGLGLGIT IAFLATLITQ FLVYNGVYQY TSPDFLYIRS WLPCIFFSGG VTVGNIGRQL AMGVPEKPHS D
靶标信息
Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: growth response protein (CL-6); Immediate-early protein CL-6; INSIG-1; INSIG-1 membrane protein; Insulin-induced gene 1 protein; Insulin-induced growth response protein CL-6; MGC1405
基因别名: 1810013C12Rik; Cl-6; Insig-1; Insig1
UniProt ID: (Mouse) Q8BGI3, (Rat) Q08755
Entrez Gene ID: (Mouse) 231070, (Rat) 64194
lipid metabolic process
triglyceride metabolic process
cholesterol biosynthetic process
response to sterol depletion
steroid metabolic process
cholesterol metabolic process
negative regulation of steroid biosynthetic process
sterol biosynthetic process
SREBP signaling pathway
inner ear morphogenesis
middle ear morphogenesis
negative regulation of fat cell differentiation
negative regulation of fatty acid biosynthetic process
palate development
cranial suture morphogenesis
negative regulation of cargo loading into COPII-coated vesicle
response to estradiol
cellular response to insulin stimulus
response to lipid
response to peptide hormone
response to fatty acid
