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Invitrogen

INSR beta Monoclonal Antibody (CT-1)

高级验证
4个已发表图片
7 篇参考文献
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说明书
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产品信息

MA5-13778

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-3 µg/mL
查看2篇已发表文章 2篇已发表文章

免疫细胞化学 (ICC/IF)

1:10-1:100
查看2篇已发表文章 2篇已发表文章

流式细胞分析 (Flow)

2 µg/test
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-

免疫沉淀 (IP)

2 µg/mL
查看3篇已发表文章 3篇已发表文章

亲和纯化 (AP)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

CT-1

抗原

A 15-mer synthetic peptide corresponding to aa Tyr-KKNGRILTLPRSNPS from the C-terminal of human insulin receptor beta-subunit (aa 1368-1382).
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偶联物

Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.4, with 0.2% BSA

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10982725

产品详细信息

MA5-13778 targets Insulin Receptor beta in ELISA, AP, FACS, ICC/IF and IP applications and shows reactivity with Human, mouse, and Rat samples.

The MA5-13778 immunogen is a 15-mer synthetic peptide corresponding to aa Tyr-KKNGRILTLPRSNPS from the C-terminal of human insulin receptor beta-subunit.

靶标信息

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CD220; CD220 beta; CD221; IGF-I receptor; Insulin receptor; insulin receptor preproprotein; IR; IR beta

基因别名: 4932439J01Rik; CD220; D630014A15Rik; HHF5; INSR; IR; IR-A; IR-B

UniProt ID: (Human) P06213, (Mouse) P15208

Entrez Gene ID: (Human) 3643, (Rat) 24954, (Mouse) 16337

功能
protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor receptor binding protein binding ATP binding GTP binding protein phosphatase binding lipoic acid binding insulin-like growth factor I binding insulin-like growth factor II binding protein complex binding 3-phosphoinositide-dependent protein kinase binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding PTB domain binding protein kinase activity transmembrane receptor protein tyrosine kinase activity protein kinase binding protein domain specific binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
参与通路
activation of MAPK activity negative regulation of protein phosphorylation positive regulation of protein phosphorylation heart morphogenesis carbohydrate metabolic process regulation of transcription, DNA-templated G-protein coupled receptor signaling pathway positive regulation of cell proliferation insulin receptor signaling pathway epidermis development male gonad development response to manganese ion regulation of hydrogen peroxide metabolic process positive regulation of glycoprotein biosynthetic process negative regulation of gene expression response to activity peptidyl-tyrosine phosphorylation transformation of host cell by virus signal transduction by protein phosphorylation male sex determination adrenal gland development positive regulation of cell migration exocrine pancreas development activation of protein kinase activity activation of protein kinase B activity response to estradiol negative regulation of transporter activity cellular response to insulin stimulus response to vitamin D response to testosterone response to tumor necrosis factor peptidyl-tyrosine autophosphorylation glucose homeostasis positive regulation of MAPK cascade positive regulation of nitric oxide biosynthetic process fat cell differentiation response to ethanol positive regulation of glycogen biosynthetic process positive regulation of DNA replication positive regulation of glycolytic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated regulation of embryonic development positive regulation of glucose import protein autophosphorylation positive regulation of developmental growth protein heterotetramerization response to glucocorticoid positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling positive regulation of respiratory burst cellular response to growth factor stimulus regulation of female gonad development protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway response to hormone response to glucose organ morphogenesis response to nutrient levels response to insulin positive regulation of phosphorylation phosphorylation intracellular signal transduction
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