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IP3 Receptor 1 Antibody (MA5-35516) in IHC (P)
Immunohistochemistry analysis of IP3 Receptor 1 in paraffin-embedded mouse brain. Samples were incubated with IP3 Receptor 1 Monoclonal antibody (Product # MA5-35516) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
MA5-35516
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1007
抗原
A synthetic peptide corresponding to a sequence within amino acids 2200-2300 of human IP3R (Q14643)
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849416
产品详细信息
Immunogen sequence: HTAQIEIVRL DRTMEQIVFP VPSICEFLTK ESKLRIYYTT ERDEQGSKIN DFFLRSEDLF NEMNWQKKLR AQPVLYWCAR NMSFWSSISF NLAVLMNLLV A
靶标信息
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名:
Inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor; Inositol 1,4,5-trisphosphate receptor type 1; Inositol 1,4,5-trisphosphate-binding protein P400; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; InsP3R type I; insP3R1; InsP>3
基因别名: D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; InsP3R; InsP3R1; Ip3r; IP3R1; Itpr-1; Itpr1; opt; P400; Pcd6; Pcp-1; Pcp1
UniProt ID: (Mouse) P11881, (Rat) P29994
Entrez Gene ID: (Mouse) 16438, (Rat) 25262
ion channel activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium channel activity
protein binding
protein C-terminus binding
calcium-release channel activity
calcium channel inhibitor activity
protein phosphatase binding
protein complex binding
phosphatidylinositol binding
ligand-gated ion channel
response to hypoxia
transport
ion transport
calcium ion transport
apoptotic process
positive regulation of cytosolic calcium ion concentration
post-embryonic development
endoplasmic reticulum calcium ion homeostasis
inositol phosphate-mediated signaling
negative regulation of calcium-mediated signaling
voluntary musculoskeletal movement
release of sequestered calcium ion into cytosol
positive regulation of calcium ion transport
transmembrane transport
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
calcium ion transmembrane transport
cellular response to cAMP
negative regulation of neuron death
cellular response to hypoxia
