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IQGAP1 Antibody (PA5-19189) in WB
Western blot analysis of IQGAP1 using IQGAP1 Polyclonal Antibody (Product # PA5-19189) (1 µg/mL) in staining of Human Kidney lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
产品信息
PA5-19189
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (KRQSGQTDPLQKEE) corresponding to the internal amino acids of IQGAP1 (aa 357-371).
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10985944
产品详细信息
This antibody is predicted to react with rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
靶标信息
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DISP2; DISPB; p195; Ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs
基因别名: HUMORFA01; IQGAP1; KIAA0051; p195; SAR1
UniProt ID: (Human) P46940
Entrez Gene ID: (Human) 8826
GTPase inhibitor activity
GTPase activator activity
calcium ion binding
protein binding
calmodulin binding
phosphatidylinositol-3,4,5-trisphosphate binding
protein kinase binding
protein phosphatase binding
protein domain specific binding
protein complex binding
protein serine/threonine kinase activator activity
S100 protein binding
Rac GTPase binding
cadherin binding involved in cell-cell adhesion
G-protein modulator
protein-binding activity modulator
GTPase-activating protein
regulation of cytokine production
signal transduction
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
negative regulation of GTPase activity
negative regulation of dephosphorylation
cellular response to platelet-derived growth factor stimulus
positive regulation of GTPase activity
positive regulation of protein kinase activity
platelet-derived growth factor receptor signaling pathway
cellular response to calcium ion
cellular response to epidermal growth factor stimulus
positive regulation of protein serine/threonine kinase activity
glomerular visceral epithelial cell development
cell-cell adhesion
neuron projection extension
