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IREB2 Antibody (PA5-64388) in IHC (P)
Immunohistochemical analysis of IREB2 in human small intestine using IREB2 Polyclonal Antibody (Product # PA5-64388) shows strong cytoplasmic positivity in glandular cells.
产品信息
PA5-64388
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2642774
产品详细信息
Immunogen sequence: EYGAILSFFP VDNVTLKHLE HTGFSKAKLE SMETYLKAVK LFRNDQNSSG EPEYSQVIQI NLNSIVPSVS GP
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
靶标信息
Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ23381; IRE-BP 2; Iron regulatory protein 2; iron-responsive element binding protein 2; Iron-responsive element-binding protein 2; IRP2
基因别名: ACO3; IREB2; IRP2; IRP2AD
UniProt ID: (Human) P48200
Entrez Gene ID: (Human) 3658
